Fulfilling the strength analysis of glass curtain wall with mullion-supporting at the action of combined loads by the finite element analysis software named ANSYS. By the calculation of glass curtain wall with mullion-supported which be constituted of beam element and shell element, then we could obtain the values of deflection and stress of every structure element correctly. Of course, we can also provide theory foundation for improving mechanical properties of total system. The calculation results show that the maximum values of stress and deflection of steel structure are 105.758 MPa and 14.156 mm corresponding for this project in all kinds of combined loads. It also be in favor of curtain regulation so that realize cutting optimization of design process. As a result of all above, this analysis method save cost of product and create more profits for curtain company.